Polyflex (Ampicillin) is an injectable penicillin suspension with broad-spectrum bactericidal properties. It works against a variety of common gram-negative and gram-positive bacteria.
Ampicillin is a bactericidal, time-dependent β-lactam antibiotic with improved activity against Gram-negative organisms when compared to penicillin, though with somewhat less activity against Gram-positive organisms. Ampicillin distributes widely through the plasma and can cross the blood-brain barrier when meninges are inflamed. It does not penetrate abscesses or sites of tissue necrosis well. Excretion is primarily in urine.
Ampicillin sodium is indicated in the treatment of susceptible strains of the organisms causing the following infections in the horse: Respiratory tract infections (pneumonia and strangles) due to Staphylococcus spp., Streptococcus spp. (including S. equi), E. coli, and Proteus mirabilis.
- When used in combination with amikacin (an aminoglycoside), for treatment of neonatal sepsis.
- For treatment of streptococcal lower airway infections.
- Can be used as IV an alternative to penicillin in most cases.
Drug & Food Interactions
When administered concurrently, the following drugs may interact with ampicillin: allopurinol, bacteriostatic antibiotics, oral contraceptives and probenecid.
Prescribing Ampicillin capsules and Ampicillin for Oral Suspension in the absence of a proven or strongly suspected bacterial infection of a prophylactic indication is unlikely to provide benefit to the pet and increases the risk of the development of drug-resistant bacteria. Prolonged use of antibiotics may promote the overgrowth of nonsusceptible organisms, including fungi. Should superinfection occur, appropriate measures should be taken. Pets with gonorrhea who also have syphilis should be given additional appropriate parenteral penicillin treatment. Treatment with ampicillin does not preclude the need for surgical procedures, particularly in staphylococcal infections.