Domidine is an injection used to sedate and provide some analgesia for horses and cattle. It facilitates examinations and minor surgical procedures to be carried out.
Each mL contains 10 mg detomidine hydrochloride.
Preservative: Contains 1.0 mg/mL methylparaben.
Domidine 10 mg/mL Indications
For use as a sedative and analgesic to facilitate minor surgical and diagnostic procedures in mature horses and yearlings.
Dosage and Administration
Administer Domidine IV or IM at the rates of 20 or 40 µg detomidine hydrochloride per kg of body weight (0.2 to 0.4 mL of Domidine per 100 kg or 220 lbs.), depending on the depth and duration of sedation and analgesia required. Analgesia is more pronounced when the drug is given IV. Sedative and analgesic effects will usually occur in 2 to 5 minutes and will persist for 30 minutes to 2 hours, depending on dosage and route of administration.
Prior to and following injection, the animal should be allowed to rest quietly. The full effect should be reached within 2 to 4 minutes after IV injection and 3 to 5 minutes after IM injection.
Domidine is not to be used in horses with pre-existing AV or SA block, with severe coronary insufficiency, cerebrovascular disease, respiratory disease, or chronic renal failure. Detomidine hydrochloride should not be used in breeding horses since the potential risk has not been assessed in either stallions or mares.
CAUTIONS: The drug is a potent α2-agonist that should be used with extreme caution with other sedatives, analgesics, or anesthetics as these are likely to produce additive effects. Careful consideration should be given prior to the administration of Domidine to horses in endotoxic or traumatic shock or approaching shock, to horses with advanced liver or kidney disease or other pre-existing conditions of stress such as extreme heat or cold, high altitude, or fatigue. Intravenous potentiated sulfonamides should not be used in anesthetized or sedated horses as potentially fatal dysrhythmias may occur. Protect treated horses from temperature extremes. Food and water should be withheld until the sedative effect of Domidine have worn off.
Keep out of reach of children. Not for use in horses that are to be slaughtered for use in food.