It is a broad-spectrum antibiotic synthetically derived from oxytetracyclin. To reduce the development of drug-resistant bacteria and maintain effectiveness and other antibacterial drugs, doxycyclin hyclate should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.
Doxycycline is a bacteriostatic, time-dependent tetracycline antibiotic with a broad spectrum of activity against many Gram-positive and Gram-negative aerobes. It is not effective against Proteus spp. or Pseudomonas spp. There is activity against some anaerobes, but efficacy against Clostridium spp. is variable. Intracellular organisms are highly susceptible. Distribution is wide, and it is the only tetracycline that effectively crosses the blood-brain barrier. Doxycycline is primarily excreted in feces.
- As an oral alternative to oxytetracycline for the treatment of anaplasmosis, Potomac Horse Fever, Lyme Disease, or leptospirosis.
- As an alternative therapy for lower respiratory disease in foals caused by β-hemolytic Streptococcus spp. or Rhodococcus equi.
- Bioavailability of doxycycline is greater in foals than adult horses; doses exceeding 10mg/kg should only be used in adult horses, and there is increased risk of diarrhea with increasing dose.
- Doxycycline should not be given parenterally to horses because of unknown safety.
Due to the possibility of fatalities, intravenous injections should not be used in horses until further studies documenting the safety of intravenous doxycycline in horses are conducted. Be sure to keep plenty of water readily available while your pet is taking this medication, as hydration helps prevent some side effects from occurring.