Ketamidor 100 mg/ml solution for injection

$59.00

Ketamidor containing ketamine 100mg/ml fits nicely in our pain management/anaesthesia portfolio.
Ketamine is a dissociative anaesthetic. Its antagonistic action on the NMDA-receptors inhibits the neurotransmitter glutamate.
The glutamate coupled acetylcholine release blocks the excitability of the neurons and therefore the transmission of neural impulses.

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Ketamidor containing ketamine 100mg/ml fits nicely in our pain management/anaesthesia portfolio.
Ketamine is a dissociative anaesthetic. Its antagonistic action on the NMDA-receptors inhibits the neurotransmitter glutamate.
The glutamate coupled acetylcholine release blocks the excitability of the neurons and therefore the transmission of neural impulses.

Dissociative anaesthesia
This means that the signal transduction between the hypothalamus and the cerebrocortical system is interrupted. Pain is not recognised as belonging to the body. Ketamidor is used in combination with alpha 2-agonists for premedication and induction of anaesthesia and is a suitable partner for all other anaesthetic and analgesic substances, e.g. opioids. Ketamine can be administered in many different ways and is part of the “Hellabrunn mixture”, used to immobilise wild and zoo animals.

Analgesia
Recent research showed that Ketamidor administered as constant rate infusion in subanaesthetic doses provides substantial analgesia, especially associated with neuropathic pain.
It can also prevent the “wind up” phenomenon, where NMDA receptors play a great role and can even partly reverse it.

Indications for use of Ketamidor, specifying the target species

To be used as a sole agent for restraint and minor surgical procedures in the cat, where muscle relaxation is not required.
To be used to induce anaesthesia:

  1. a)  in combination with detomidine in the horse.
  2. b)  in combination with xylazine in the horse, in cattle, dog and in the cat.
  3. c)  in combination with azaperone in the pig.
  4. d)  in combination with medetomidine in the dog and cat.
  5. e)  in combination with diazepam in the dog.

Contraindications of Ketamidor

Do not use:

  •   in animals with severe cardiac de-compensation, suspected pulmonary disease,

    apparent high blood pressure, or cerebrovascular insults.

  •   in animals with pre-existing liver and kidney pathology.
  •   in eclampsia, pre-eclampsia, glaucoma and seizure disorders (e.g. epilepsy).
  •   for surgical intervention on pharynx, larynx, trachea or bronchial tree, if sufficient

    relaxation is not ensured by administration of a muscle relaxant (intubation obligatory).

HORSE
Pre-medication with a sedative is required for a sufficient anaesthetic effect:

To induce anaesthesia

With detomidine:
Detomidine 20 μg/kg IV, after 5 minutes
Ketamine 2.2 mg/kg fast IV (2.2 ml/100 kg)
The onset of action is gradual, taking approximately 1 minute to attain recumbency, with the duration of anaesthetic effect lasting approximately 10 – 15 minutes.

With xylazine:
Xylazine 1.1 mg/kg IV, followed by
Ketamine 2.2 mg/kg IV (2.2 ml/100 kg)
The onset of action is gradual, taking approximately 1 minute, with the duration of the anaesthetic effect being variable and lasting 10 – 30 minutes but usually less than 20 minutes.

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