Regu-Mate Solution Indicated to suppress estrus in mares. Regu-Mate Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. 1000ml. Regu-mate is used to suppress estrus in mares by reducing undesirable behavior and moods during their heat cycle.
Each mL of Regu-Mate Solution (altrenogest) Solution 0.22% contains 2.2 mg of altrenogest in an oil solution.
Indications for Regu-Mate Solution
Regu-Mate Solution (altrenogest) Solution 0.22% is indicated to suppress estrus in mares. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Suppression of estrus will also facilitate management of prolonged estrus conditions. Suppression of estrus may be used to facilitate scheduled breeding during the physiological breeding season.
Contraindications of Regu-Mate Solution
Regu-Mate (altrenogest) Solution 0.22% is contraindicated for use in mares having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis). Natural or synthetic gestagen therapy may exacerbate existing low-grade or “smoldering” uterine inflammation into a fulminating uterine infection in some instances.
Various synthetic progestins, including altrenogest, when administered to rats during the embryogenic stage of pregnancy at doses many fold greater than the recommended equine dose caused fetal anomalies, specifically masculinization of the female genitalia.
Dosage and Administration
While wearing protective gloves, remove shipping cap and seal; replace with enclosed plastic dispensing cap. Remove cover from bottle dispensing tip and connect luer lock syringe (without needle). Draw out appropriate volume of Regu-Mate solution. (Note: Do not remove syringe while bottle is inverted as spillage may result.) Detach syringe and administer solution orally at the rate of 1 mL per 110 pounds body weight (0.044 mg/kg) once daily for 15 consecutive days. Administer solution directly on the base of the mare’s tongue or on the mare’s usual grain ration. Replace cover on bottle dispensing tip to prevent leakage. Excessive use of a syringe may cause the syringe to stick; therefore, replace syringe as necessary.