Boehringer Ingelheim Sedivet (romifidine hydrochloride) 1.0% Injection is indicated for use as a sedative and analgesic to facilitate handling, clinical examinations, clinical procedures, and minor surgical procedures in adult horses. Sedivet 1.0% Injection is also indicated as a preanesthetic prior to the induction of general anesthesia in adult horses.
High-quality sedation makes it easier to perform veterinary procedures and handle the horse, as well as being easier and gentler on the horse. Factors that indicate quality sedation include:
- Rapid sedation
- Minimal head drop
- Minimal ataxia
- Smooth recovery
Dosage and administration
For intravenous use only. A dose range of 0.4 – 1.2 ml Sedivet/100 kg bodyweight (equivalent to 40 to 120 micrograms romifidine HCl/kg) gives a dose-related response.
Onset of action, which is independent of dose, is 1 – 2 minutes. Maximum sedation is achieved after 5 – 10 minutes. Please see the chart below
SEDIVET’s onset of action begins within approximately 30 seconds following administration. Horses given SEDIVET may not exhibit normal signs of sedation, such as markedly pronounced head drop or ataxia, so the actual onset may occur without typical notice.
Minimal Head Drop
Sedated horses normally appear relaxed with a lowered head; however, a head too low following sedation can make it difficult to perform certain veterinary procedures.
With SEDIVET, lowered head position is a minimal side effect, making it ideal for head and neck procedures.
Important Safety Information: As with other drugs of this class, the administration of Sedivet 1.0% Injection causes bradycardia, first and second degree atrioventricular heart block and hypotension. The frequency and duration of cardiac arrhythmias have been shown to be dose related. Use care to not over-sedate based on degree of head drop or ataxia as these may not be reliable indicators of sedation depth.
Recovering smoothly from sedation is key to several areas:
- minimizing injury that can result from attempting to stand while recovering
- reducing stress on the horse
- reassuring the horse owner
With SEDIVET, you can be confident that the horse will normally be able to stand on the first attempt without injury. In one study, recovery was excellent in 90 percent of horses evaluated.