Seramune Equine IgG has been developed to be used prophylactically in all foals whether nursing normally or with probable FPT. Seramune Equine IgG is a low-cost, effective management tool to improve passive immunity overall. Fifteen to twenty foals can be protected for the treatment cost for each foal treated for the diseases resulting from FPT.
A foal’s survival is riding on the care it receives the first few hours after birth. Normally, the foal receives protection from its mother’s first milk or colostrum. Unfortunately, some foals do not or cannot nurse, and therefore become immunodeficient. Made from equine serum, Seramune provides instant, reliable protection and gives foals enough IgG for protection in those first few weeks of life. Administer orally in two even amounts (150 ml each) 1-2 hours apart, within the first 12 hours of life.
Testing foals prior to twelve hours of life can give false results (from an already variable test) since the plasma volume in the foal can be 30% lower than at 12 hours and absorption may still be taking place at twelve hours. The gut begins to close to the absorption of colostrum immunoglobulins very rapidly. The first twelve hours of life is the critical time period for ingestion of antibodies. This is the optimum window of opportunity to influence passive immunity — that is, when colostrum and Seramune Equine IgG oral absorption is most effective. Testing foals for IgG suspected of FPT would be optimal at 18-24 hours of age when blood/plasma volumes have leveled off.
Immunological Activity of Equine IgG
When immunoglobin is given orally, IgG and IgM are absorbed by the gut and pass into the bloodstream. Some of the IgA also passes into the bloodsream. Part of the IgA is used to coat exposed cells lining the gut. IgG and IgM neutralize harmful viruses and bacteria in the bloodstream and spaces surrounding cells. The IgA remaining in the gut cavity prevents adherence and replication of pathogens, thus preventing an outbreak of infection which the treated animal may be unable to prevent with only naturally acquired immunoglobins.