SYNEDEM is an Anti-edematose, diuretic, anti-inflammatory. Many veterinarians use this drug combination in horses to reduce mild swellings, particularly of the legs. SYNEDEM works at the level of the proximal tubules of the kidneys to decrease the reabsorption of sodium. It has little effect on potassium excretion. A full discussion of the anti-inflammatory effects and side effects associated with dexamethasone are discussed in the SYNEDEM monograph. One of the benefits of using a combination product is that each component works by a different mechanism. This may allow a smaller dose of the individual drugs than might be used if the drug were given individually.
SYNEDEM is indicated for the treatment of edema, (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema. It is an effective diuretic possessing a wide therapeutic range. Pharmacologically it promotes the rapid removal of abnormally retained extracellular fluids. The rationale for the efficacious use of diuretic therapy is determined by the clinical pathology producing the edema. The continued use of heart stimulants, such as digitalis or its glycosides, is indicated in cases of edema involving cardiac insufficiency. It is a highly effective diuretic-saluretic which if given in excessive amounts may result in dehydration and electrolyte imbalance, enhancing the risk of circulatory collapse, thrombosis, and embolism. The animal should be observed for early signs of fluid depletion with electrolyte imbalance, and corrective measures should be administered. See package insert for full information regarding contraindications, warnings, and precautions. Synedem-Over Categories: Dr Martin Selection, Dexa, Percentage, Moderate dose : 0,1 to 0,4% (or 1 to 4mg/ml), Supplemented or Additives, With Diuretic, Most Popular, Anti-inflammatories & Pain Relievers, Diuretics
Every 100 ml, it contains:
Fursemide 5 g
Dexamethasone (21 phosphate) 0.2 g
Formulation Agents e.q.
Administration and Dosages:
Intramuscular or intravenous slow injection.
Large animals: 10-25 ml per 12 o 24 hours, according to professional criteria.
Small animals: 0.25-0.5 ml every 5 k.l.w. per day, according to professional criteria.
bottle 25 ml. (each Box comes with 12 bottles)