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Xylapan 20mg Solution for Injection

$80.00

Xylapan is a clear colourless aqueous sterile solution for injection. Each ml of Xylapan contains xylazine hydrochloride 23.32 mg (equivalent to xylazine 20.00 mg) with methyl parahydroxybenzoate (E218) 0.65 mg and propyl parahydroxybenzoate (E216) 0.35 mg as preservatives. Xylazine is an alpha 2 adrenergic agonist with sedative, analgesic and muscle relaxant properties. In cattle, the degree of sedation can be predetermined according to the dose administered.

Xylapan is a clear colourless aqueous sterile solution for injection. Each ml of Xylapan contains xylazine hydrochloride 23.32 mg (equivalent to xylazine 20.00 mg) with methyl parahydroxybenzoate (E218) 0.65 mg and propyl parahydroxybenzoate (E216) 0.35 mg as preservatives. Xylazine is an alpha 2 adrenergic agonist with sedative, analgesic and muscle relaxant properties. In cattle, the degree of sedation can be predetermined according to the dose administered.

Xylapan Uses

For use in horses, cattle, dogs and cats where sedation is required. The main indications for use include the following:
General handling and transport of nervous or fractious animals.
Medical examinations and treatments such as X-rays or oral, genital and rectal examination.
Premedication for minor surgical interventions and for anaesthesia in combination with other analgesics, narcotics and inhalant anaesthetics.
Dosage and administration of Xylapan
Syringes and needles must be sterile. Clean area of injection site and swab with spirit.
It should be noted that dosage and routes of administration vary widely between species.
An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes.
Cattle
Administer by intramuscular injection.
The dose rate of Xylapan is 0.05-0.3 mg/kg body weight (0.25 – 1.5 ml/100 kg body weight) according to the degree of sedation required. Very fractious animals may require higher dose rates not exceeding 0.3 mg/kg bodyweight (Dose rate 4).
Dose
mg/kg
mg/50 kg
ml/50 kg
1
0.05
2.5
0.125
2
0.10
5.0
0.25
3
0.20
10.0
0.50
4
0.30
15.0
0.75
The degree of sedation can be predetermined according to the dose administered:
Dose 1: Sedation, with a slight decrease of muscle tone. The ability to stand is maintained.
Dose 2: Sedation, marked decrease of muscle tone and some analgesia. The animal usually remains standing, but may lie down.
Dose 3: Deep sedation, further decrease of muscle tone and a degree of analgesia. The animal lies down.
Dose 4: Very deep sedation, a profound decrease in muscle tone and a degree of analgesia. The animal lies down.
After doses 3 and 4 cattle are likely to remain drowsy for several hours and should be kept in the shade.
Animals should not be disturbed until xylazine has taken its full effect. The first effects are usually seen within 5 minutes of injection and the maximum effect is produced ten minutes later. There is no struggling or excitement during induction or recovery.
If the required depth of sedation is not achieved it is unlikely that repetition of the dose will prove more effective. Repeating the procedure with a higher dose after 24 hours is recommended.
For any surgical treatment, additional local anaesthesia should be employed.
Horses
Administer Xylapan by slow intravenous injection, taking from one to two minutes. The dose rate is 0.6 – 1 mg/kg body weight (3-5 ml/100 kg body weight) according to the degree of sedation required and the response of the animal.
Depending on the dosage, light to deep sedation with individually variable analgesia is obtained. The horse does not become recumbent.
Nervous or highly excitable animals generally require a higher dose.
Older horses and those that have undergone severe physical exertion before treatment respond more readily to Xylapan.
Animals should not be disturbed until xylazine has taken its full effect. This is usually within five minutes of intravenous injection and lasts for approximately 20 minutes.
If the required depth of sedation is not achieved it is unlikely that repetition of the dose will prove more effective. Repeating the procedure with a higher dose after 24 hours is recommended.
For painful operations, additional local or regional anaesthesia should be used.
The product can also be administered to horses as premedication for operations on the recumbent animal using chloral hydrate, barbiturates, ketamine or halothane.
Contra-indications, warnings, etc
Xylapan is contraindicated for use at the latter stages of pregnancy except at parturition.
Because of the emetic effect which is sometimes produced, the product should not be used in cats and dogs with mechanical complications of the alimentary tract such as obstruction of the oesophagus, gastric torsion, or hernia.
Horse
Following intravenous injection, there is a transient rise followed by a fall of blood pressure.
The usual precautions required for handling should always be observed even when a high dose of Xylapan is given.
Cattle
In recumbent cattle, tympany should be prevented by maintaining sternal recumbency.
For operations in lateral or dorsal recumbency, it is advisable to lower the head and neck in order to avoid inhalation of the saliva or rumenal fluids. When high doses are to be employed the animal should fast for some hours beforehand.
After dose levels 3 or 4, cattle are likely to remain drowsy for several hours and should be kept in the shade.

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